Warning: Illegal string offset 'itemscope' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1153
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1153
Warning: Illegal string offset 'itemtitle' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1154
Warning: Illegal string offset 'itemurl' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1155
Warning: Illegal string offset 'itemtext' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1156
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1156
Warning: Illegal string offset 'itemgenre' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1157
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1157
Warning: Illegal string offset 'itemlang' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1158
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1158
Warning: Illegal string offset 'createdate' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1159
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1159
Warning: Illegal string offset 'modifydate' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1160
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1160
Warning: Illegal string offset 'published' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1161
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1161
Warning: Illegal string offset 'author' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1162
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1162
Warning: Illegal string offset 'authorname' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1163
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1163
Warning: Illegal string offset 'interaction' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1164
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1164
Warning: Illegal string offset 'eventstart' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1167
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1167
Warning: Illegal string offset 'eventend' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1168
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1168
Warning: Illegal string offset 'eventadress' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1169
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1169
Warning: Illegal string offset 'eventlocality' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1170
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1170
Warning: Illegal string offset 'eventregion' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1171
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1171
Warning: Illegal string offset 'eventpostal' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1172
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1172
Warning: Illegal string offset 'eventprice' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1173
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1173
Warning: Illegal string offset 'eventtickets' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1174
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1174
Warning: Illegal string offset 'eventoffers' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1175
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1175
Warning: Illegal string offset 'eventprint' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1176
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1176
Warning: Illegal string offset 'preptime' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1179
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1179
Warning: Illegal string offset 'cooktime' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1180
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1180
Warning: Illegal string offset 'totaltime' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1181
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1181
Warning: Illegal string offset 'ingredients' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1182
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1182
Warning: Illegal string offset 'recipeprint' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1183
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1183
Warning: Illegal string offset 'directors' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1186
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1186
Warning: Illegal string offset 'writters' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1187
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1187
Warning: Illegal string offset 'moviestars' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1188
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1188
Warning: Illegal string offset 'movieprint' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1189
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1189
Warning: Illegal string offset 'videolink' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1192
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1192
Warning: Illegal string offset 'videothumb' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1193
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1193
Warning: Illegal string offset 'videoduration' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1194
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1194
Warning: Illegal string offset 'videoprint' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1195
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1195
Warning: Illegal string offset 'productprice' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1198
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1198
Warning: Illegal string offset 'availability' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1199
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1199
Warning: Illegal string offset 'productprint' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1200
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1200
Warning: Illegal string offset 'bookprice' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1203
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1203
Warning: Illegal string offset 'bookavailability' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1204
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1204
Warning: Illegal string offset 'bookoffers' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1205
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1205
Warning: Illegal string offset 'bookpages' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1206
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1206
Warning: Illegal string offset 'bookauthor' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1207
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1207
Warning: Illegal string offset 'bookpublisher' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1208
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1208
Warning: Illegal string offset 'booklanguage' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1209
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1209
Warning: Illegal string offset 'bookprint' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1210
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1210
Warning: Illegal string offset 'category' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1213
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1213
Warning: Illegal string offset 'microdata' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1216
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1216
Warning: array_keys() expects parameter 1 to be array, string given in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1225
Warning: array_fill_keys() expects parameter 1 to be array, null given in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1225
Notice: Undefined property: stdClass::$category in
/home2/bioscree/public_html/plugins/system/yjsg/includes/html/com_content/category/blog.php on line
52
>
Consumer Products Toxicological Safety Assessments
BioScreen offers safety assessment by a board certified toxicologist for any product type. Safety assessments are suitable for use in the following areas:
- EU registration
- Documenting product safety in lieu of clinical testing
- Adjuct to clinical testing
In-vitro Eye
Optisafe in vitro Ocular Irritation AssayTM
The OptiSafeTM in vitro ocular irritation test is a standardized and quantitative acute ocular irritation test method that can be used to determine the irritation potential of cosmetics, creams, shampoos, toiletries, cleaning agents and a wide variety of consumer products.
Why Use the the OptiSafe in vitro Ocular Irritation Test?
Animal testing of cosmetics and personal care products is discouraged in the U.S. and banned in Europe. The E.U. requires non animal safety testing and the FDA requires safety testing or a warning within the Principal Display Panel (PDP) that the product has not been tested. OptiSafeTM can be used for:
- Satisfaction of FDA labeling requirements
- Due diligence to test whether the product is safe
- Product longevity: products that irritate do not last long in the marketplace
Test Description
OptiSafeTM Test:
- The product to be tested is applied to a semi-permeable membrane (”ocular membrane") which is a material developed to be similar to the layer of tissue on the outside of the cornea.
- When the sample moves through the ocular membrane, it contacts a macromolecular matrix. This matrix has one component that issimilar in structure and organization to macromolecules within the cornea and a second component that predicts damage to molecules related to the immune response and cell viability.
- Irritants induce a change in the optical density (measured with a spectrophotometer).
- The level of opacity and damage to specific molecules has been found to predict the sample’s irritation potential.
The Advantages of OptiSafeTM include:
- High Accuracy Ocular Irritancy Test
- High Sensitivity for Mild and Moderate Irritants
- Low Cost
- Fast Results
- Neither uses nor harms animals
- Satisfies minimal labeling requirements for Cosmetics, Personal Care and other Consumer Products.
The OptiSafeTM in vitro Assay Method has demonstrated value as a screening tool for a broad variety of consumer products.
HET-CAM Severe Ocular Irritation and Corrosion Assay
Early stage fertile hens eggs are used to determine if a substance is a severe ocular irritant or corrosive. Effects are measured by the onset of (1) hemorrhage; (2) coagulation; and (3) vessel lysis. The method followed is as described: NIH publication No. 10-7553- Published 2010: HET-CAM IS(A). Because early stage eggs are used this test is considered a non-animal test.
EpiOcularTM OECD 492
The OptiSafeTM in vitro Acute Ocular Irritation Test Method is a standardized, comprehensive and quantitative acute ocular irritation test system that predicts ocular irritation based on a substance's potential for macromolecule disruption.
Short Time Exposure OECD 491
The STE test method is a cytotoxicity-based in vitro assay that is performed on a confluent monolayer of Statens Seruminstitut Rabbit Cornea (SIRC) cells. After exposure to a test chemical, the cytotoxicity is quantitatively measured as the relative viability of SIRC cells using the MTT assay. Decreased cell viability is used to predict potential adverse effects leading to ocular damage.
BCOP OECD 437
The BCOP test method is an organotypic model that provides short-term maintenance of normal physiological and biochemical function of the bovine cornea in vitro. In this test method, damage by the test chemical is assessed by quantitative measurements of changes in corneal opacity and permeability with an opacitometer and a visible light spectrophotometer, respectively. Both measurements are used to calculate an IVIS, which is used to assign an in vitro irritancy hazard classification category for prediction of the in vivo ocular irritation potential of a test chemical.
In-vitro Derm
EpiDermTM SIT OECD 439
The RhE test system uses human derived non-transformed keratinocytes as cell source to reconstruct an epidermal model with representative histology and cytoarchitecture.
EpiDermTM SCT OECD 431 ECVAM Protocol for EPIDERM (EPI-200)
The RhE test method is based on findings that chemicals are able to penetrate the stratum corneum by diffusion or erosion, and are cytotoxic to the cells in the underlying layers. Cell viability is measured by enzymatic conversion of the vital dye MTT, into a blue formazan salt that is quantitatively measured after extraction from tissues. Corrosive chemicals are identified by their ability to decrease cell viability below defined threshold levels. The RhE-based skin corrosion test methods have shown to be predictive of in vivo skin corrosion effects assessed in rabbits according to the OECD guideline 404.
EpiDermTM (PGA) packing group assignment
The test is designed to predict and classify the skin corrosivity potential of a chemical by assessment of its effect on a reconstituted three-dimensional human epidermis which can be used to predict packing groups.
Oral Toxicity
Acute Oral Toxicity Range-finding. OECD 24
The NRU in vitro basal cytotoxicity assay procedure is based on the ability of viable cells to incorporate and bind neutral red (NR), a supravital dye. NR is a weak cationic dye that readily diffuses through the plasma membrane and concentrates in lysosomes where it electrostatically binds to the anionic lysosomal matrix. Toxicants can alter the cell surface or the lysosomal membrane to cause lysosomal fragility and other adverse changes that gradually become irreversible. Such adverse changes cause cell death and/or inhibition of cell growth, which then decrease the amount of NR retained by the culture. Since the concentration of NR dye desorbed from the cultured cells is directly proportional to the number of living cells, cytotoxicity is expressed as a concentration-dependent reduction of the uptake of NR after chemical exposure. The NRU assay uses a 96-well plate format for the production of replicate measurements at eight test substance concentrations.